Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats
Identifieur interne : 000029 ( Istex/Curation ); précédent : 000028; suivant : 000030Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats
Auteurs : K. Nagashima [Allemagne] ; H. Wege [Allemagne] ; R. Meyermann [Allemagne] ; V. Ter Meulen [Allemagne]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1979-01-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Allergic encephalomyelitis, Animal model, Astrocytic processes, Axon, Basement membrane, Brain suspension, Chronic relapsing, Clinical signs, Control animals, Corona, Corona virus, Demyelinated areas, Demyelinating, Demyelinating encephalomyelitis, Demyelinating lesions, Demyelinating plaques, Demyelination, Disease process, Electron microscopy, Encephalomyelitis, Federal republic, Glial, Glial cells, Incubation period, Inoculation, Intracerebral inoculation, Late onset, Lesion, Light microscopy, Long incubation period, Lower part, Mononuclear cells, Mouse hepatitis virus, Multiple sclerosis, Murine corona virus, Myelin, Myelin sheaths, Nagashima, Naked axon, Naked axons, Neurological signs, Neuropathol, Optic nerve, Optic tract, Peripheral myelin, Peripheral nerves, Plaque, Present study, Remyelinated areas, Remyelination, Schwann, Schwann cell, Schwann cells, Sclerosis, Sheath, Small cells, Spinal, Spinal cord, Spinal tract, Subacute demyelinating encephalomyelitis, Trigeminal, Trigeminal nerve, Trigeminal nerves, Ultrastructural study, Upper corner, Vesicular disruption, Viral antigen, Virus inoculation, Weanling rats, White matter.
Abstract
Summary: About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.
Url:
DOI: 10.1007/BF00702672
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Ter Meulen</name><affiliation wicri:level="1"><mods:affiliation>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology and Immunobiology, University of Würzburg, Versbacher Straße 7, D-8700, Würzburg</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1979-01-01">1979-01-01</date><biblScope unit="volume">45</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="205">205</biblScope><biblScope unit="page" to="213">213</biblScope></imprint><idno type="ISSN">0001-6322</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Corona virus rats</term><term>Late onset demyelination</term><term>Multiple sclerosis</term><term>Remyelination</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acta</term><term>Acta neuropathol</term><term>Allergic encephalomyelitis</term><term>Animal model</term><term>Astrocytic processes</term><term>Axon</term><term>Basement membrane</term><term>Brain suspension</term><term>Chronic relapsing</term><term>Clinical signs</term><term>Control animals</term><term>Corona</term><term>Corona virus</term><term>Demyelinated areas</term><term>Demyelinating</term><term>Demyelinating encephalomyelitis</term><term>Demyelinating lesions</term><term>Demyelinating plaques</term><term>Demyelination</term><term>Disease process</term><term>Electron microscopy</term><term>Encephalomyelitis</term><term>Federal republic</term><term>Glial</term><term>Glial cells</term><term>Incubation period</term><term>Inoculation</term><term>Intracerebral inoculation</term><term>Late onset</term><term>Lesion</term><term>Light microscopy</term><term>Long incubation period</term><term>Lower part</term><term>Mononuclear cells</term><term>Mouse hepatitis virus</term><term>Multiple sclerosis</term><term>Murine corona virus</term><term>Myelin</term><term>Myelin sheaths</term><term>Nagashima</term><term>Naked axon</term><term>Naked axons</term><term>Neurological signs</term><term>Neuropathol</term><term>Optic nerve</term><term>Optic tract</term><term>Peripheral myelin</term><term>Peripheral nerves</term><term>Plaque</term><term>Present study</term><term>Remyelinated areas</term><term>Remyelination</term><term>Schwann</term><term>Schwann cell</term><term>Schwann cells</term><term>Sclerosis</term><term>Sheath</term><term>Small cells</term><term>Spinal</term><term>Spinal cord</term><term>Spinal tract</term><term>Subacute demyelinating encephalomyelitis</term><term>Trigeminal</term><term>Trigeminal nerve</term><term>Trigeminal nerves</term><term>Ultrastructural study</term><term>Upper corner</term><term>Vesicular disruption</term><term>Viral antigen</term><term>Virus inoculation</term><term>Weanling rats</term><term>White matter</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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